Sunresin
Sunresin is an innovation oriented high-tech enterprise, specialized in supplying Ion exchange resins, adsorption & separation resins, equipment solutions and relevant technical services.
With almost 20 years of manufacturing experience, it is the listed company in the IER industry (Shenzhen Stock code 300487) which provides a high level of transparency to its customers.
Sunresin manufactures about 50,000M³ of ion exchange resins and adsorbers annually, supplying furthermore customers with tens of adsorption and separation equipment.
Sunresin's resin portfolio include about 25 product categories and more than 200 different resin types which are broadly used in industries such as: Water and Waste water treatment, Food Processing, Biotech, Pharmaceuticals, Plant Extraction, Membrane Caustic Soda, Hydrometallurgy, as well as Municipal Water Treatment among others.
Sunresin is dedicated to the industrialization of newly developed polymeric resins as well as to the exploitation of applications in emerging industries. The core technologies for all special resin products and equipments are of its Independent Intellectual Property Rights
The Company holds more than 30 patents – in China and internationally - and has accomplished more than ten national projects in the area of resin development. Sunresin is certified under ISO 9001 for Quality Control System and ISO14001 for Environment Control System.
Sunresin provides excellent and high quality products to the market. All the employed manufacturing processes are strictly controlled by the environmental regulations. [->]
Sunresin is certified with : Halal | Kosher | ISO9001:2015 | ISO14000:2015 | FDA Certificate | WQA Gold seal certificate | CE certificate | RoHS Test | REACH | Chinese National Science and Technology Progress Awards
Categories includes : Powder Resins | Chromatographic Resins | Solid Phase Peptide Synthesis | Lxa Adsorbent Resin | Industrial scale (Chromatographic purification)
Vast varieties of products are available under each categories.
Categories
Powder Resins
It is an insoluble and supplied as a dry, fine powder, which is suitable for use in pharmaceutical applications. Sunresin is transforming pharmaceutical formulations with its innovative medicinal powder resins. These water-insoluble polymers feature a unique mesh-like structure capable of exchanging ions with those in a solution. Classified into cation and anion exchange resins based on the ions they exchange, and further distinguished by their acid-base properties into strong and weak acids or bases, these resins excel in enhancing drug efficacy. Their superior ion exchange capabilities enable rapid drug disintegration, controlled release, bitterness reduction, stability improvement, enhanced dissolution, and minimized adverse reactions. Ideal for a variety of dosage forms—ranging from tablets and capsules to gels and liquids—Sunresin's medicinal powder resins are a cornerstone of modern pharmaceutical development.
In addressing flavor masking, sustained release, improving drug stability, and disintegration for pharmaceutical applications, Sunresin has independently developed and produced strong cation exchange resins with a polystyrene-divinylbenzene polymer skeleton and weak anion exchange resins with a polymethylacrylate-divinylbenzene skeleton. These resins play an outstanding role in various drug inhibitors.
Available grades are : Calcium Polystyrene Sulphonate - LX98 | Cholestyramine resin - LPF860 | Polacrilex resin - LX100 (IRP 64) | Polacrilin Potassium - LX200 (IRP 88) | Sodium Polystyrene Sulphonate - LX400
Powder Resins Applications
| Application | Method |
|---|---|
| Sustained and Controlled Release Formulations | Sunresin's ion exchange resins excel in forming stable drug-resin complexes, ensuring a consistent and controlled drug release. This process is primarily governed by the interaction with endogenous ions (K+, Na+, Cl-) in the gastrointestinal tract, making it independent of dietary influences and pH variations. Our resins, composed of high molecular weight, water-insoluble polymers, are designed to engage in a reversible ion exchange process. This means they don't get absorbed by the body but actively swap ions with gastric and intestinal fluids. This unique interaction releases the drug in a controlled manner, allowing for precise drug delivery within the digestive system. |
| Flavor Masking with Ion Exchange Resins | Sunresin employs advanced ion exchange resins, high molecular weight polymers equipped with activatable groups, to adeptly mask the unpleasant tastes and odors of drugs through electrostatic adsorption. This process encapsulates ionic drugs within the resin's framework, significantly enhancing patient compliance by neutralizing tastes before they can be detected. Due to the specific pH conditions in the mouth (around 6.8), where the sense of taste is less acute and saliva secretion is minimal, these resin-drug complexes have a brief oral residency time. This ensures that the drug does not release its bitter taste before reaching the stomach. The effectiveness of this flavor masking technology varies with the drug involved, generally employing a resin-to-drug ratio between 0.1 and 0.75. This innovative approach has been successfully utilized in formulations of medications like ranitidine and paroxetine, illustrating its significant impact on improving patient medication adherence. |
| Enhancing Drug Stability | Sunresin enhances the stability of sensitive drugs by encapsulating them within the protective polymer framework of our advanced ion exchange resins. This method effectively shields drugs from environmental stressors like temperature fluctuations, light, humidity, and potential contaminants, which can compromise drug integrity and efficacy. By creating drug-resin complexes, we not only prevent degradation but also minimize interactions between compounds in mixed formulations, significantly boosting the overall stability of the drug. A notable example is Vitamin B12, a compound known for its sensitivity to light and pH extremes, which sees a dramatic increase in shelf life—from a mere three months to over two years—when formulated as a resin complex. This process not only extends the drug's viability but also protects it from stomach acid, enhancing absorption and effectiveness. Through this innovative approach, Sunresin is setting new standards for drug formulation, ensuring longer shelf life, and improving the bioavailability of essential medications. |
| Promoting Drug Dissolution | Sunresin's ion exchange resins play a crucial role in enhancing the dissolution of insoluble drugs. While not directly increasing the solubility of drugs, our resins significantly boost the rate at which drugs dissolve, surpassing the performance of raw drug materials. This is achieved through the formation of drug-resin complexes that transform drugs into an amorphous state, facilitating immediate ion exchange with solvents upon dissolution. This process eliminates the need for drugs to overcome their lattice energy, allowing for rapid release into the body. |
| Minimizing Adverse Reactions | Sunresin's innovative approach utilizes ion exchange resins to encapsulate irritating drugs within their polymer frameworks, significantly reducing the drugs' direct contact with the sensitive tissues of the gastrointestinal tract. This strategic encapsulation prevents the drug from irritating the mouth, pharynx, esophagus, and stomach lining—areas often susceptible to adverse reactions like ulcers from oral medications. By doing so, Sunresin enhances patient comfort and safety, ensuring a smoother therapeutic experience with minimized risk of gastrointestinal distress. |
| Therapeutic Applications | Sunresin's ion exchange resins transcend traditional drug formulation, offering targeted therapeutic treatments for a spectrum of medical conditions. Engineered with precision, these resins are pivotal in managing hyperacidity, ulcers, electrolyte imbalances (notably sodium and potassium depletion), kidney diseases, and edema linked to cardiac and pancreatic issues. |
Specifications of Powder Resins
| Contact us for specifications |
|---|
Top FAQs on Powder Resins
Chromatographic Resins
The Chromatographic Resin is a new design, through excellent processing technology and high-quality raw materials, the performance of Chromatographic Resin up to a higher standard. We are perfect for every detail of the Chromatographic Resin, guarantee the quality level, so as to bring you the perfect product experience. Sunresin is a professional China Chromatographic Resin manufacturer and supplier, if you are looking for the best Chromatographic Resin with low price, consult us now!
Available grades are : SP Seplife® FF Agarose | CM Seplife® FF Agarose | NI Seplife® 6FF (IDA) Affinity | Seplife® G Series Dextran
i) SP Seplife® FF Agarose
Agarose matrix, SP group, fast flow, Equivalent to SP Sepharose FF
SP seplife® FF chromatography resin is a new highly cross-linked agarose chromatography resin independently developed by Sunresin. It is a kind of sulfonic acid-based propyl bonded on agarose gel filtration chromatography resin. Strong cation exchange chromatography resin with high flow rate, low back pressure, high dynamic loading, good chemical stability and mechanical properties, low non-specific adsorption, high recovery rate, convenient scale-up, shortening production time and improving Productivity. It is widely used in ion exchange separation of proteins, nucleic acids and peptides downstream of biopharmaceuticals and bioengineering.
SP Seplife® FF Agarose parameters
| Parameters | Value |
|---|---|
| Appearance | White Sphere beads |
| Particle size(μm) | 45～165 |
| Matrix | Seplife 6FF |
| Flow rate(cm/h) | <750 |
| pH stability | 4~13 (long term), 3~14 (Short term, CIP) |
| Application | Proteins, nucleic acids and peptides downstream of biopharmaceuticals and bioengineering |
ii) CM Seplife® FF Agarose
Agarose matrix, CM group, fast flow, Equivalent to CM Sepharose FF
CM seplife® FF chromatography medium is a new type of highly cross-linked agarose chromatography medium independently developed by Sunresin. It is a weak cation formed by bonding carboxymethyl groups to agarose gel filtration chromatography medium. Ion exchange chromatography media. It has high flow rate, low back pressure, high dynamic load, good chemical stability and mechanical properties, low non-specific adsorption, high recovery rate, easy to scale up, can shorten production time and improve production efficiency. Widely used in ion exchange chromatography purification of downstream proteins, nucleic acids and peptides in biopharmaceuticals and bioengineering.
CM Seplife® FF Agarose parameters
| Parameters | Value |
|---|---|
| Appearance | White Sphere beads |
| Particle size(μm) | 45～165 |
| Matrix | Seplife 6FF |
| Flow rate(cm/h) | <750 |
| pH stability | 4~13 (long term), 3~14 (Short term, CIP) |
| Application | Proteins, nucleic acids and peptides downstream of biopharmaceuticals and bioengineering |
iii) NI Seplife® 6FF (IDA) Affinity
Processing of protein, nucleic acid and polypeptide purification
Ni Chelating Agarose Chromatography (IDA) is binding iminodiacetic acid on 6FF agarose media and then chelating ion of Ni2+ to be as an affinity chromatographic media. It is widely used for the processing of protein, nucleic acid and polypeptide purification in down stream of biopharming and bioengineering.
Ni Seplife® 6FF (IDA) Affinity parameters
| Parameters | Value |
|---|---|
| Appearance | Sphere gel beads |
| Particle size(μm) | 45～165 |
| Matrix | Seplife 6FF |
| Flow rate(cm/h) | ≥370 |
| pH stability | 3~13 (long term), 2~14 (Short term, CIP) |
| Application | His-tag protein purification |
iv) Seplife® G series Dextran
The Seplife® dextran ion exchange chromatography resins use the dextran matrix of G series gel filtration chromatography resins (Seplife G-25 and Seplife G-50), and the ion exchange functional ligands of different properties are firmly bonded to the cross-linked dextran matrix.
Dextran ion exchange resins are usually stored in the form of dry powder, which must be swollen before use. It is widely used in low molecular weight proteins such as prothrombin and low molecular weight heparin.
Industrial scale (Chromatographic purification)
SEPLITE® CM2610 / CM2610S are fillers with divinylbenzene polymer backbone and C18 linear alkanes as functional groups. It provides different separation options from polystyrene-divinylbenzene filler for the preparation and purification of small biological molecules.
Unlike traditional polystyrene-divinylbenzene copolymerized inverse fillers, it uses C18 long linear chains as functional groups. Due to the different functional groups that provide hydrophobic force, it brings a different chromatographic behavior from traditional polystyrene-divinylbenzene packing. At the same time, the polymerization method is used to obtain a filler containing C18 linear alkanes, which has stronger alkali resistance compared to silica gel filler. Soaking in 1 M NAOH solution for 600 hours will not reduce the separation effect.
Compared with the reversed C18 silica gel filler, the higher specific surface area also brings a higher loading capacity. Narrow particle size distribution and good heat treatment process make the swelling capacity of the packing smaller, and lower back pressure at high flow rate, which can be widely used in industrial-scale chromatographic purification.
SEPLITE® CM2610 / CM2610S parameters
| Parameters | CM2610 | CM2610S |
|---|---|---|
| Appearance | White spherical particles | |
| Particle Size (㎛ ) | 50-75 | 30-50 |
| Bulk density (g/ml) | 0.69 | |
| Density (g/ml) | 0.94 | |
| Moisture Content (%) | 45-55 | |
| Specific surface area (m2/g) | ≥200 | |
| Pore size | 250-350 | |
Solid Phase Peptide Synthesis
i) Wang Resin
Used for the solid phase immobilization of acids and phenols for SPOS
Wang resin is the most widely used resin for SPOS. As a standard support it can be used for the solid phase immobilization of acids and phenols for SPOS. The ester linkage may be achieved, which has good stability to a variety of reaction conditions, but can be readily removed with the moderate acid treatment, generally with TFA. For the immobilization of amines, Wang resin also can be readily converted into solid phase equivalents of standard urethane-based protecting groups by reaction with phosgene or activated carbonates, such as carbonyl diimidazole or bis(p-nitrophenyl)-carbonate.
ii) 2-Chlorotrityl Chloride Resin
Use in the preparation of peptides containing C-terminal Cys, His, Met, Tyr and Pro residues.
An extremely acid-labile resin for preparing peptides and partially protected peptide fragments by the Fmoc strategy. This resin is ideal for use in the preparation of peptides containing C-terminal Cys, His, Met, Tyr and Pro residues. Cleavage for protected peptides from this matrix can be effected by treatment with AcOH/TFE/DCM,0.5% TFA or HFIP. Fully deprotected peptides can also be obtained by cleaving with 95% TFA in the usual manner.
iii) Rink Amide Resin
Excellent support for the Fmoc SPPS of peptide amides
Rink amide resin is an excellent support for the Fmoc SPPS of peptide amides. This resin is more acid sensitive than Rink Amide-AM and Rink Amide-MBHA resins. Cleavage with high concentrations of TFA can lead to the breakdown of the linker, with the concomitant formation of by-products that can not be removed by simple washes. These problems appear to be minimized through the use of low TFA concentrations or by the addition of trialkylsilanes to the cleavage mixture.
iv) Sieber Resin
support suited to the synthesis of secondary carboxamides
A hyper acid-labile linker or the Fmoc SPPS of protected amides via mild 1% TFA cleavage. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides. This resin has also been employed to produce protected peptide fragments in wich the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester.
Adsorbent Resin
Adsorbent resins are the designable Macroporous Polymer adsorbents, usually used in plant extraction, pharmaceuticals purification, juice decolorization.
The earliest adsorbent used by humans is activated carbon, which has a large specific surface area (500-1700 m2/g). It can remove pollutants from water by physical adsorption, chemical adsorption and ion exchange adsorption. In addition, it demonstrates excellent gas adsorption characteristics.
The macroporous adsorbent is a kind of high molecular polymer, which combines the principles of adsorption and molecular sieve to concentrate and separate organic substances.
The macroporous adsorbent is prepared by suspension polymerization. Its physicochemical properties are stable, insoluble in acids, bases and organic solvents. Its porogen、skeleton and polarity could been designed to meet all kinds of separation requirement.
The macroporous adsorbent selectively adsorbs organic substances from the solution by physical adsorption, thereby achieving the purpose of separation and purification.
It has good selectivity to organic matter, is not affected by the presence of inorganic salts and strong ions and low molecular compounds, and can be adsorbed by swelling in water and organic solvents.
- Juice decolorization, odor removal, citrus debittering, and removal of pesticides
- Stevioside Purification
- Plant extraction industry
- Antibiotic purification industry
- Organic wastewater treatment
- Organic VOC gas treatment
- Separation industry of enzymes, amino acids and peptides
Certificates
- Allergen, Contaminants, Elemental impurities, Gluten, GMO, Melamine, Nitrosamine, Pesticide, Residual solvent, TSE-BSE