Solid Phase Peptide Synthesis

What is Solid Phase Peptide Synthesis

i) Wang Resin

Used for the solid phase immobilization of acids and phenols for SPOS

Wang resin is the most widely used resin for SPOS. As a standard support it can be used for the solid phase immobilization of acids and phenols for SPOS. The ester linkage may be achieved, which has good stability to a variety of reaction conditions, but can be readily removed with the moderate acid treatment, generally with TFA. For the immobilization of amines, Wang resin also can be readily converted into solid phase equivalents of standard urethane-based protecting groups by reaction with phosgene or activated carbonates, such as carbonyl diimidazole or bis(p-nitrophenyl)-carbonate.

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Sunresin is an innovation oriented high-tech enterprise, specialized in supplying Ion exchange resins, adsorption & separation resins, equipment solutions and relevant technical services.

With almost 20 years of manufacturing experience, it is the listed company in the IER industry (Shenzhen Stock code 300487) which provides a high level of transparency to its customers.

Sunresin manufactures about 50,000M³ of ion exchange resins and adsorbers annually, supplying furthermore customers with tens of adsorption and separation equipment.

Sunresin's resin portfolio include about 25 product categories and more than 200 different resin types which are broadly used in industries such as: Water and Waste water treatment, Food Processing, Biotech, Pharmaceuticals, Plant Extraction, Membrane Caustic Soda, Hydrometallurgy, as well as Municipal Water Treatment among others.

Sunresin is dedicated to the industrialization of newly developed polymeric resins as well as to the exploitation of applications in emerging industries. The core technologies for all special resin products and equipments are of its Independent Intellectual Property Rights

The Company holds more than 30 patents – in China and internationally - and has accomplished more than ten national projects in the area of resin development. Sunresin is certified under ISO 9001 for Quality Control System and ISO14001 for Environment Control System.

Sunresin provides excellent and high quality products to the market. All the employed manufacturing processes are strictly controlled by the environmental regulations. More Info

Categories includes : Powder Resins | Chromatographic Resins | Solid Phase Peptide Synthesis | Lxa Adsorbent Resin | Industrial scale (Chromatographic purification)

Vast varieties of products are available under each categories.

ii) 2-Chlorotrityl Chloride Resin
Use in the preparation of peptides containing C-terminal Cys, His, Met, Tyr and Pro residues.

An extremely acid-labile resin for preparing peptides and partially protected peptide fragments by the Fmoc strategy. This resin is ideal for use in the preparation of peptides containing C-terminal Cys, His, Met, Tyr and Pro residues. Cleavage for protected peptides from this matrix can be effected by treatment with AcOH/TFE/DCM,0.5% TFA or HFIP. Fully deprotected peptides can also be obtained by cleaving with 95% TFA in the usual manner.

iii) Rink Amide Resin
Excellent support for the Fmoc SPPS of peptide amides

Rink amide resin is an excellent support for the Fmoc SPPS of peptide amides. This resin is more acid sensitive than Rink Amide-AM and Rink Amide-MBHA resins. Cleavage with high concentrations of TFA can lead to the breakdown of the linker, with the concomitant formation of by-products that can not be removed by simple washes. These problems appear to be minimized through the use of low TFA concentrations or by the addition of trialkylsilanes to the cleavage mixture.

iv) Sieber Resin
support suited to the synthesis of secondary carboxamides

A hyper acid-labile linker or the Fmoc SPPS of protected amides via mild 1% TFA cleavage. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides. This resin has also been employed to produce protected peptide fragments in wich the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-Î²-alaninamide ester.