Microcrystalline Cellulose (MCC)

What is Microcrystalline Cellulose?

Microcrystalline Cellulose, commonly known as MCC, is a widely used pharmaceutical excipient for solid dosage formulations such as tablets and capsules.

MCC is mainly used as a binder, filler, diluent, and disintegrating support excipient in pharmaceutical and nutraceutical formulations. It is valued for its good compressibility, powder flow improvement, water absorption, and disintegration-supporting properties.

In tablet manufacturing, MCC helps improve formulation performance during direct compression, wet granulation, rotary tablet pressing, high-speed tablet manufacturing, and capsule filling.

We represent

Huzhou City Linghu Xinwang Chemical Co., Ltd. is a high-tech enterprise specializing in the research, development, production, and sales of pharmaceutical excipients, food additives, and specialty ingredients. Established in 2000 and located in Zhejiang Province, China, the company combines technical expertise with advanced manufacturing capabilities.

Its portfolio includes pharmaceutical excipients and formulation ingredients that support diverse industry applications. Backed by ISO 9001 and ISO 22000 certifications, Linghu Xinwang focuses on quality, innovation, and continuous product development to meet evolving market requirements. More Info

KP Manish represents MCC present across : China

MCC is certified with : Halal ,Kosher, ISO 9001,ISO22000 , Nitrosamine free

Products offered are : MCC pH Series , XC Series, XT Series ,HD Series, SMC Series

Applications areas of MCC

MCC is a versatile excipient used in a wide range of pharmaceutical and nutraceutical applications.

Segment	Application
Direct Compression	Direct compression tablets
Granulation	Wet granulation formulations, Dry granulation formulations
Tablet Manufacturing	Rotary tablet pressing, High-speed tablet manufacturing
Specialized Tablets	Buccal tablets, Chewable tablets
Sensitive Formulations	Multiple-dose tablet formulation, Low-dose tablet formulation
Suspensions	Suspensions and dry suspensions
Nutraceuticals	Nutraceutical tablets and capsules

MCC acts as a filler, binder, diluent and flow-support excipient, helping to improve compressibility, flowability, disintegration and overall formulation performance.

Benefits of MCC

Excellent Binding Capability
Superior Compression Performance
Enhanced Powder Flow Properties
Improved Content & Weight Uniformity
Reliable Disintegration Support

Specifications

MCC PH Series (Standard Direct Compression Grades)

Grade	Moisture	D50	Key Feature
PH-101	≤7.0%	50 µm	Standard grade for wet granulation, rotary tablet pressing and pill making
PH-102	≤7.0%	100 µm	Larger particle size, suitable for direct compression with good flowability and compressibility
PH-200	≤7.0%	200 µm	Large particle size, suitable for high-speed tablet press and tablet weight control
PH-112	≤0.8%	100 µm	Low-moisture PH-102 type for water-sensitive medicine

MCC XC Series (Low Lubrication grades)

Grade	Moisture	Bulk Density	D50	Key Feature
XC-802	≤7.0%	0.18–0.30 g/cm³	50 µm	High-performance excipient with formability about twice that of PH type
XC-1000	≤7.0%	0.10–0.35 g/cm³	50 µm	Excellent formability, small dosage can meet tablet hardness requirements

MCC XT Series( High Compressibility Grades)

Grade	Moisture	Bulk Density	D50	Key Feature
XT-711	≤7.0%	0.20–0.26 g/cm³	50 µm	Combination of high formability and high flowability
XT-702	≤7.0%	0.26–0.32 g/cm³	100 µm	Best fluidity with good formability

MCC HD Series(High Density Grades)

Grade	Moisture	Bulk Density	D50	Key Feature
HD-401	≤7.0%	0.45–0.65 g/cm³	50 µm	Based on MCC 301, the bulk density was increased to improve powder fluidity.
HD-402	≤7.0%	0.45–0.65 g/cm³	100 µm	Based on MCC 302, the bulk density was increased to further improve powder fluidity.

SMCC Series(Silicified MCC Grades)

Grade	Moisture	Bulk Density	Particle Size	Key Feature
SMCC 50	≤ 6.0%	0.25 – 0.37 g/cm³	50 µm	Suitable for formulations requiring high tablet hardness and good flowability
SMCC 90	≤ 6.0%	0.25 – 0.37 g/cm³	100 µm	Suitable for formulations requiring uniform flow and compaction
SMCC 90HD	≤ 6.0%	0.38 – 0.50 g/cm³	100 µm	Provides excellent flowability and firmness with fast disintegration time
SMCC 90LM	≤ 1.5%	0.27 – 0.39 g/cm³	100 µm	Similar to SMCC 90, but with lower moisture content (<1.5%)

Top FAQs on MCC

Microcrystalline Cellulose (MCC) is a widely used pharmaceutical excipient used as a binder, filler, diluent, and disintegrant in tablet and capsule formulations. It is valued for its excellent compressibility, flowability, and formulation-supporting properties.

MCC is commonly used in tablets and capsules to improve powder flow, tablet hardness, compressibility, and overall manufacturing efficiency. It is suitable for direct compression, wet granulation, and capsule filling applications.

MCC supports direct compression, improves powder flowability, enhances tablet hardness, promotes uniform tablet weight, and enables efficient high-speed tablet production.

MCC functions as a binder, filler, diluent, and disintegrant support excipient. It helps improve tablet strength, content uniformity, and disintegration performance.

MCC PH-102 and MCC PH-200 are commonly preferred for direct compression due to their larger particle size, excellent flowability, and compressibility characteristics.

MCC PH-101 has a smaller particle size and is typically used in wet granulation processes. MCC PH-102 has a larger particle size, offering better flowability and making it suitable for direct compression applications.

Low-moisture grades such as MCC PH-112 are suitable for moisture-sensitive formulations, helping maintain product stability while providing excellent compressibility and flow properties.

Yes. MCC grades such as PH-200 are designed to deliver excellent flowability and tablet weight consistency, making them suitable for high-speed tablet presses.

Microcrystalline Cellulose is derived from purified plant-based cellulose through a controlled hydrolysis process. It is widely used in pharmaceutical and nutraceutical formulations due to its functionality and reliability.

The appropriate MCC grade depends on factors such as compression method, particle size requirements, flowability, moisture sensitivity, tablet hardness targets, and manufacturing speed. Selecting the right grade helps optimize formulation performance and production efficiency.